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KMID : 0370219980420050527
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Yakhak Hoeji
1998 Volume.42 No. 5 p.527 ~ p.533
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The Evaluation of Antifungal Activities and Safeties of 6- ( 3 , 4-Dichlorophenyl ) amino-7-Chloro-5 , 8- Quinolinedione
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윤여표/Yun YP
김동현/이병무/허문영/정해문/강혜영/최정아/김도희/유충규/Kim DH/Lee BM/Heo MY/Chung HM/Kang HY/Choi JA/Kim DH/Ryu CK
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Abstract
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6-(3,4-Dichlorophenyl)amino-7-chloro-5,8-quinolinedione (RCK50) was tested for antifungal activities in mice systemically infected with Candida albicans. The therapeutic potential of RCK50 was also assessed in comparison with ketoconazole. CK50 had ED50 0.22 +/- 0.01mg/kg. Ketoconazole as a positive control had ED50 6.00 +/- 1.70mg/kg. Intraperitoneally administered RCK50 at the ED50 for 7 days and 14 days reduced Candida albicans colony count in the kidneys and liver. And administered RCK50 at the ED50 for 14 days improved survival rates. The genotoxicities of RCK50 had been evaluated. RCK50 was negative in Ames test with Salmonella typhimurium and chromosomal aberration test in CHL cells. RCK50 did not show any clastogenic effect in mouse peripheral blood and was negative in mouse micronucleus assay. These results indicate that RCK50 has no genotoxic potential under these experimental conditions. Acute oral toxicity studies of RCK50 were carried out in ICR mice of both sexes. RCK50 did not show acute oral toxicities and LD50 values were over 2,850mg/kg in ICR mice.
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KEYWORD
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